However, in 2009, Wyle returned to ER during its fifteenth and final season for five episodes, including the series finale.
According to the Guinness World Records 2005 Special 50th Anniversary Edition, Wyle became the holder of a "Highest paid TV drama actor per episode" record during the 2003–2004 tenth season, earning approximately 0,000 per episode.
Noah met his first wife, make-up artist Tracy Warbin, on the set of The Myth of Fingerprints.
They married in 2000 and have a son, Owen Strausser Speer Wyle (born November 9, 2002), and a daughter, Auden Wyle (born October 15, 2005).
with three children of his own from a previous marriage.
Wyle's paternal grandparents, Edith and Frank Wyle, founded the Los Angeles Craft and Folk Art Museum, and his grandfather also founded Wyle Laboratories.
With the company, he has appeared on stage in the 1995 production of The 24th Day with Peter Berg, The Who (as part of the company's Young Playwrights Festival), and Lobster Alice, opposite Nicholas Brendon, where he played the surrealist painter Salvador Dalí.
For his work as one of the producers of 2005 Los Angeles Production of Michael John La Chiusa's The Wild Party, he won an NAACP Theatre Award.
Along with his film and television career, Wyle is also Artistic Producer of The Blank Theatre Company located in Hollywood, California.While on ER, Wyle's estimated salary was million a year.Wyle was first seen in the Paul Bartel film Lust in the Dust (a western exploitation/parody which starred Tab Hunter, Lainie Kazan, and Divine) as an extra in the local gang running the small town of Chile' Verde.Wyle and Warbin separated in 2009 and divorced in 2010.Wyle opened the 1999 NY Macworld Expo keynote, initially posing as Apple Inc.'s Steve Jobs.
It was a practical joke on the audience, engineered by Jobs and Wyle in light of the 1999 TNT film, Pirates of Silicon Valley.